• Home
  • Contact
Dude Magazine
  • Business
  • Technology
  • Automotive
  • Health
  • Home Improvement
  • Travel
  • Home
  • Uncategorized
  • PALMITOYLETHANOLAMIDE: ANTI-INFLAMMATORY AGENT AND A GUARD AGAINST INFLUENZA AND COMMON COLD

PALMITOYLETHANOLAMIDE: ANTI-INFLAMMATORY AGENT AND A GUARD AGAINST INFLUENZA AND COMMON COLD

June 2, 2020 Comments Off on PALMITOYLETHANOLAMIDE: ANTI-INFLAMMATORY AGENT AND A GUARD AGAINST INFLUENZA AND COMMON COLD

Palmitoylethanolamide (PEA) is a meal element acknowledged for longer than 50 years. PEA is amalgamated and metabolized by various animal cell samples and also existing in plants. It exerts a multitude of physiological functions related to metabolic and cellular homeostasis. PEA was previously recognized in the 50s of the latest era as a therapeutic element with potent anti-inflammatory characteristics.

Since 1970, the anti-inflammatory and additional immune-modulating features of PEA have been manifested in several placebo-controlled double-blind clinical experiments on influenza and the usual cold. Positive results coincided with the clinical use of PEA in former Czechoslovakia under the brand name Impulsion.

ANTI-INFLAMMATORY MECHANISM AND ACTION (APPLICATION) OF PALMITOYLETHANOLAMIDE

MECHANISM:

  • In an artistic research on the anti-inflammatory and pro-apoptotic motions of anandamide, it was revealed that it can hinder tumor necrosis factor-α-induced NF-κB activation [18]. The NF-κB inhibitory activity of anandamide was independent of CB1 and CB2. Structure-activity relationships demonstrated that analogs with saturated fatty acyl groups were more active than unsaturated analogs. Saturated acylethanolamines such as PEA, therefore, offer a new opportunity to modify chronic inflammation in autoimmune disorders.

  • Starting with Professor Rita Levi-Montalcini’s work, it became clear that PEA regulates many pathophysiological processes, and PEA has since been found to be effective in a number of animal models for inflammation, neuroinflammation, neurotoxicity, and chronic pain. Levi-Montalcini highlighted the importance of activation of inflammatory cascades via the activation of nonneuronal cells, such as mast cells.

ACTION (APPLICATION):

  • Micronized and ultra-micronized PEA possessed superior pharmacological action against carrageenan-induced inflammatory pain, in contrast to the preparation of non-micronized PEA, which failed to show efficacy when orally given in this model. The anti-inflammatory action of PEA combined with an antioxidant could potentiate its pharmacological effects. Amidst the essential molecules that can neutralize the peroxidation processes, there are numerous flavonoids, such as Luteolin, Polydatin, Quercetin, and Silymarin, which hold different pharmacological conclusions and treatments.
  • A mixture of PEA and Baicalein has been latterly investigated in a myocardial I/R damage type. In this study, treatment with PEA-Baicalein was shown to reduce myocardial tissue injury, neutrophil infiltration, markers for expression of mast cell activation, such as chymase and tryptase, and pro-inflammatory cytokine production (TNF-α and IL-1β). Moreover, operation with PEA-Baicalein decreased nitrotyrosine and PAR configuration, repressed NF-kB nuclear translocation, and accentuated apoptosis pathways.

FINAL CONCLUSION:

PEA is a universal material provided by the body and discovered in numerous foods. It is not an opioid or addictive. Preparatory readings designate that PEA does not advance pharmacological toleration or progressively fall effectiveness over time as happens with opioids.

It is harmless for patients with no recorded serious side impacts like Pterostilbene and it is contemplated to lack intense or chronic toxicity. It does not meddle with other vaccination therapies nor does it trigger drug-drug communications.

Post navigation

Togel lottery and pool games – Useful tips for picking the best game!!
The master making of the garden Room

Related Articles

Why Roofing Companies Should Invest in SEO to Stay Competitive

Michael Thompson
May 26, 2025May 26, 2025 Comments Off on Why Roofing Companies Should Invest in SEO to Stay Competitive

Full-Service Sacramento Junk Outfits

Michael Thompson
March 11, 2024March 11, 2024 Comments Off on Full-Service Sacramento Junk Outfits

How Casimba Canada’s Free Spins Can Boost Your No Deposit Play

Michael Thompson
March 1, 2024March 1, 2024 Comments Off on How Casimba Canada’s Free Spins Can Boost Your No Deposit Play

Link

white label ppc

Categories

  • Automotive
  • Business
  • Casino
  • crypto
  • dating
  • dental
  • drug
  • Education
  • Entertainment
  • Fashion
  • Food
  • Gambling
  • game
  • gaming
  • Health
  • Home Improvement
  • home improvment
  • Internet marketing
  • Law
  • maintenance
  • Pet
  • Security
  • social media
  • Spiritual
  • Sports
  • Stream
  • Streaming
  • Technology
  • trading
  • Travel
  • Uncategorized
  • Wedding

Contact Us

[contact-form-7 id=”130″ title=”Contact form 1″]

Recent Posts

15 Изумительные проститутки Краснодара в телеграме feyakrd

Michael Thompson - dating
June 18, 2025June 18, 2025 Comments Off on 15 Изумительные проститутки Краснодара в телеграме feyakrd

Проститутки в Краснодаре являются просто невероятными любовницами, которые способны довести...

Top Free Presentation Makers Similar to Canva for Any Project

June 13, 2025June 14, 2025

Eleven Free Players That Could Fit Real Valladolid’s Strategy

June 12, 2025June 12, 2025

Reducing Water Usage in Chip Fabrication: Innovations and Best Practices

May 30, 2025May 30, 2025

Lessons from the Dot-Com Bubble: Are Today’s Tech Valuations Repeating History? – Kavan Choksi / カヴァン・チョクシ

May 30, 2025May 30, 2025

Building the Perfect Gravel Bike Setup: Tires, Gearing, and Gear That Matter Most – Steven Rindner

May 30, 2025May 30, 2025

Latest Posts

15 Изумительные проститутки Краснодара в телеграме feyakrd

June 18, 2025June 18, 2025

Top Free Presentation Makers Similar to Canva for Any Project

June 13, 2025June 14, 2025

Eleven Free Players That Could Fit Real Valladolid’s Strategy

June 12, 2025June 12, 2025

Reducing Water Usage in Chip Fabrication: Innovations and Best Practices

May 30, 2025May 30, 2025

Link

บาคาร่า

Featured

Calendar

June 2025
M T W T F S S
 1
2345678
9101112131415
16171819202122
23242526272829
30  
« May    
Copyright 2020 dude-magazine.com | All rights reserved | Theme: OMag by LilyTurf Themes
  • Technology
  • Business
  • Health
  • Automotive
  • Travel
  • Fashion